Aegle Therapeutics is a pioneer in regenerative medicine developing extracellular vesicle (EV) therapy to meaningfully improve the lives of those suffering from debilitating rare diseases, including dystrophic epidermolysis bullosa (DEB) and other severe dermatological disorders. Aegle’s platform technology has the potential to treat a wide range of other therapeutic indications.

About Us

We are a clinical-stage developer of novel, cell-free therapies using EVs to deliver a natural biomolecular payload to treat disorders with significant unmet medical need.

Understanding EVs

EVs are the body’s mechanism to deliver biomolecules, such as nucleic acids and proteins, to cells and contain signals capable of stimulating or reprogramming cell function.

AGLE-102

A therapeutic composite of EVs, including exosomes, isolated from mesenchymal stem cells (MSCs) using our proprietary EV harvesting technology.

Recent Publications

Schulman CI, Namias N, Pizano L, Rodriguez-Menocal L, Aickara D, Guzman W, Candanedo A, Maranda E, Beirn A, McBride JD, Badiavas EV. The effect of mesenchymal stem cells improves the healing of burn wounds: a phase 1 dose-escalation clinical trial. Scars Burn Heal. 2022 Jun 28;8:20595131211070783.


McBride et al. Proteomic analysis of bone marrow-derived mesenchymal stem cell extracellular vesicles from healthy donors: implications for proliferation, angiogenesis, Wnt signaling and the basement membrane. Stem Cell Res Ther 12, 328 (2021).